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KMID : 0357919730070020103
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Korean Journal of Pathology
1973 Volume.7 No. 2 p.103 ~ p.109
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Experimental Studies on Relationship between Hyperplastic Hepatic Nodule and Hepatic Megalocytosis of the Liver
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김종만(金鍾萬)/Chong Man Kim
김용일(金勇一)/이제구(李濟九)/Yong Il Kim/Chae Koo Lee
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Abstract
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Experimental induction of hyperplastic hepatic nodules was carried out by administra-
tion of p-dimethylaminoazobenzene in rats, to correlate with hepatic megalocytosis and
to clarify sequence of precancerous lesion.
Hyperplastic hepatic nodules and megalocytosis were induced in most of rats following
administration of p-DAB : megalocytosis developed during the initial phase (before the
12th wk) of carcinogenesis, and showed a tendency to spread panlobularly from
periportal distribution. Those paralleled with increase of compensatory mitotic index
following hepatic cell damages by ingestion of p-DAB. Megalocytic index diminished
during the phase of hyperplastic nodules and hepatocellular carcinomas, and illustrated
no direct relationship with carcinogenesis.
Number of hyperplastic nodules regressed with prolongation of experimental duration
after cessation of administrating p-DAB.
There was a strong evidence to indicate that megalocytosis and compensatory
proliferation of hepatocytes would preceed in the p-DAB induced hepatic carcinogenesis
and the latter only undergoes into precancerous phase of hyperplastic hepatic nodule.
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KEYWORD
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